1,2,3,4-Tetrahydroisoquinoline → HCID 5102913, compound

HRID 876600Notes

Reaction equation

HRID 876600 reaction equation
F[C:2]1(F)[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([I:16])[CH:11]=2)=[O:9])[CH2:4]C1.IC1C=C(C=CC=1)C(O)=O.C1C2C(=CC=CC=2)CCN1>>[I:16][C:12]1[CH:11]=[C:10]([C:8]([N:5]2[CH2:4][CH2:2][CH2:7][CH2:6]2)=[O:9])[CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 120603-Iodobenzoic acidHCID 58181859HCID 58181859, compound

Product 1

HCID 5102913HCID 5102913, compound

Procedure

According to Step 77-1 in the synthetic method for compound 77-1, 3-iodobenzoic acid 1 and pyrrolidine 2 were used to obtain compound 87-1.

Sources & evidence

ORD record
ord-2695b791841443dca56fb5e8d7cc8e37
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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