HRID876610

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2733960

Thiophene-2-boronic acid

C4H5BO2S

HCID44119349

[2-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)phenyl]boronic acid

C14H25BO3Si

结构：O=C(Nc1ccc(-c2noc(=O)[nH]2)cc1)[C@H](O)[C@H]1OCCN(c2ccc(I)cc2)C1=O

HCID136337790

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(-c2noc(=O)[nH]2)cc1)[C@H](O)[C@H]1OCCN(c2ccc(-c3ccccc3CCO)cc2)C1=O

HCID136337789

未命名化合物

收率 33.7%

PROCEDURE

实验过程

According to the Step 22-1 in synthetic method for EXAMPLE 22, compound 106-2 (30 mg) and [2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]phenyl]boronic acid (31.4 mg) were used instead of 14-4 and 2-thiopheneboronic acid to obtain compound 106-3 (10 mg) as a colorless amorphous solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e0588d488ab4356bd3055ead7776472
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08987242B2
来源说明: uspto-grants-2015_03

反应 SMILES

[OH:1][C@H:2]([C@H:18]1[O:23][CH2:22][CH2:21][N:20]([C:24]2[CH:29]=[CH:28][C:27](I)=[CH:26][CH:25]=2)[C:19]1=[O:31])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[NH:16][C:15](=[O:17])[O:14][N:13]=2)=[CH:8][CH:7]=1)=[O:4].CC([Si](C)(C)[O:37][CH2:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1B(O)O)(C)C.S1C=CC=C1B(O)O>>[OH:1][C@H:2]([C@H:18]1[O:23][CH2:22][CH2:21][N:20]([C:24]2[CH:29]=[CH:28][C:27]([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][C:40]=3[CH2:39][CH2:38][OH:37])=[CH:26][CH:25]=2)[C:19]1=[O:31])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[NH:16][C:15](=[O:17])[O:14][N:13]=2)=[CH:8][CH:7]=1)=[O:4]