HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodobenzoic acid → 2-hydroxy-N-[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]-2-[3-oxo-4-(p-tolyl)thiomorpholin-2-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodobenzoic acid | HCID 12060 | — |
| Reactant | 4,4-Difluoropiperidine | HCID 2758352 | — |
| Reactant | 2-Hydroxy-2-[3-oxo-4-(p-tolyl)thiomorpholin-2-yl]acetic acid | HCID 67222108 | — |
| Reactant | HCID 178507458 | HCID 178507458 | — |
| Product | 2-hydroxy-N-[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]-2-[3-oxo-4-(p-tolyl)thiomorpholin-2-yl]acetamide | HCID 136337791 | 60.4% |
Reaction Steps
According to the Step 77-1 in synthetic method for EXAMPLE 77, compound 112-2 (0.55 g) and 3-(4-aminophenyl)-1,2,4-oxadiazol-5(2H)-one (0.52 g) were used instead of 3-iodobenzoic acid and 4,4-difluoropiperidine to obtain compound 112-3 (0.52 g) as a pale yellow amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987242B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-5ec943429378488ab6f5fa5e8d2a9d94 |
| Source note | uspto-grants-2015_03 |