HCID 67222484, compound → HCID 67222241, compound

HRID 876617Notes

Reaction equation

HRID 876617 reaction equation
[ClH:1].C([N:9]1[CH2:14][CH2:13][O:12][CH:11]([CH:15]([OH:21])[C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:10]1)C1C=CC=CC=1>CCO>[ClH:1].[OH:21][CH:15]([CH:11]1[O:12][CH2:13][CH2:14][NH:9][CH2:10]1)[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Participants

3

Reactant 1

HCID 67222484HCID 67222484, compound

Product 1

HCID 67222241HCID 67222241, compoundYield 101.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the Step 33-1 in synthetic method for EXAMPLE 33, compound 115-2 (0.9 g) with EtOH was used instead of EXAMPLE 32 to obtain compound 115-3 (0.65 g) as pale yellow amorphous solid.

Sources & evidence

ORD record
ord-83bdf006093b47c6b724d142ceabb33d
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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