4-Methylbenzoyl Chloride → HCID 67222363, compound

HRID 876618Notes

Reaction equation

Cl.[OH:2][CH:3]([CH:9]1[O:14][CH2:13][CH2:12][NH:11][CH2:10]1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1.S(Cl)(C)(=O)=O>>[OH:2][CH:3]([CH:9]1[O:14][CH2:13][CH2:12][N:11]([C:20](=[O:21])[C:19]2[CH:23]=[CH:24][C:16]([CH3:15])=[CH:17][CH:18]=2)[CH2:10]1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

Reactant 3

HCID 134054-Methylbenzoyl Chloride

HCID 31297Methanesulfonyl chloride

HCID 67222241HCID 67222241, compound

Product 1

HCID 67222363HCID 67222363, compoundYield 31.2%

Procedure

According to the Step 28-1 in synthetic method for EXAMPLE 28, compound 115-3 (0.2 g) and 4-methylbenzoyl chloride (164 mg) were used instead of 26-5 and mesyl chloride to obtain compound 115-4 (85 mg) as a pale yellow amorphous solid.

Sources & evidence

ORD record: ord-3e47a0c0f0444f0ca898013cd7a59c34
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987242B2

Reaction notes

Loading…