HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodobenzoic acid → HCID 136337792, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodobenzoic acid | HCID 12060 | — |
| Reactant | 4,4-Difluoropiperidine | HCID 2758352 | — |
| Reactant | 2-Hydroxy-2-[4-(4-methylbenzoyl)morpholin-2-yl]acetic acid | HCID 67223088 | — |
| Reactant | HCID 178507458 | HCID 178507458 | — |
| Product | HCID 136337792 | HCID 136337792 | 64.6% |
Reaction Steps
According to the Step 77-1 in synthetic method for EXAMPLE 77, compound 115-5 (74 mg) and 3-(4-aminophenyl)-1,2,4-oxadiazol-5(2H)-one (70.4 mg) were used instead of 3-iodobenzoic acid and 4,4-difluoropiperidine to obtain compound 115-6 (75.1 mg) as a pale yellow amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987242B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-50cfe7e83b6a4680896e18454b94da7f |
| Source note | uspto-grants-2015_03 |