Sodium Carbonate → HCID 178513342, compound

Participants

Reaction Conditions

Reaction Steps

4-cyano-3-fluoroaniline (10 g, 0.0735 mol) was dissolved in EtOH (36.7 ml) and water (7.3 ml), Na2CO3 (5.06 g, 0.65 eq) was added. The mixture was heated at 60° C. and a solution of NH2OH.HCl (5.615 g, 1.1 eq) in water (7.3 ml) was added slowly, the mixture was heated at 60° C. overnight. The mixture was cooled to 0° C., and the solid collected by filtration. Washed with water (7 ml), EtOH (7 ml), Et2O (20 ml) and dried to give 7.5 g of compound 139-1.

Provenance & Evidence