HCID 58290751, compound → HCID 131732590, compound

HRID 876629Notes

Reaction equation

HRID 876629 reaction equation
[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[NH:21][C:20](=[O:25])[CH:19]=[CH:18]3)[C:10]1=[O:26])[C:6](O)=[O:7])(=[O:3])[CH3:2].[NH2:27][C:28]1[CH:47]=[CH:46][C:31]2[C:32]([N:35]3[C:43](=[O:44])[C:42]4[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=4)[C:36]3=[O:45])=[N:33][O:34][C:30]=2[CH:29]=1>>[O:45]=[C:36]1[C:37]2[C:42](=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:43](=[O:44])[N:35]1[C:32]1[C:31]2[CH:46]=[CH:47][C:28]([NH:27][C:6](=[O:7])[C@H:5]([O:4][C:1](=[O:3])[CH3:2])[C@H:9]3[O:14][CH2:13][CH2:12][N:11]([C:15]4[CH:16]=[C:17]5[C:22](=[CH:23][CH:24]=4)[NH:21][C:20](=[O:25])[CH:19]=[CH:18]5)[C:10]3=[O:26])=[CH:29][C:30]=2[O:34][N:33]=1

Participants

3

Reactant 2

HCID 58290751HCID 58290751, compoundHCID 67032946HCID 67032946, compound

Product 1

HCID 131732590HCID 131732590, compound

Procedure

According to the Step 15-1 in the synthetic method for Example aa15, (2R)-2-acetyloxy-2-[(2R)-3-oxo-4-(2-oxo-1H-quinolin-6-yl)morpholin-2-yl]acetic acid (compound aa3-3) and 6-amino-3-(1,3-dioxoisoindol-2-yl)-1,2-benzisoxazole can be used to obtain [(1R)-2-[[3-(1,3-dioxoisoindol-2-yl)-1,2-benzisoxazol-6-yl]amino]-2-oxo-1-[(2R)-3-oxo-4-(2-oxo-1H-quinolin-6-yl)morpholin-2-yl]ethyl]acetate (compound ap1-1), then further treatment can be achieved according to the Step 15-2 to obtain the title compound ap1.

Sources & evidence

ORD record
ord-4ed107dd93e54efda3181604d77c58ac
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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