HCID 58290751, compound → HCID 131732591, compound

HRID 876630Notes

Reaction equation

HRID 876630 reaction equation
[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:24]=[C:23]3[C:18]([CH:19]=[CH:20][C:21](=[O:25])[NH:22]3)=[CH:17][CH:16]=2)[C:10]1=[O:26])[C:6](O)=[O:7])(=[O:3])[CH3:2].[NH2:27][C:28]1[CH:47]=[CH:46][C:31]2[C:32]([N:35]3[C:43](=[O:44])[C:42]4[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=4)[C:36]3=[O:45])=[N:33][O:34][C:30]=2[CH:29]=1>>[O:45]=[C:36]1[C:37]2[C:42](=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:43](=[O:44])[N:35]1[C:32]1[C:31]2[CH:46]=[CH:47][C:28]([NH:27][C:6](=[O:7])[C@H:5]([O:4][C:1](=[O:3])[CH3:2])[C@H:9]3[O:14][CH2:13][CH2:12][N:11]([C:15]4[CH:24]=[C:23]5[C:18]([CH:19]=[CH:20][C:21](=[O:25])[NH:22]5)=[CH:17][CH:16]=4)[C:10]3=[O:26])=[CH:29][C:30]=2[O:34][N:33]=1

Participants

3

Reactant 2

HCID 58290751HCID 58290751, compoundHCID 67032768HCID 67032768, compound

Product 1

HCID 131732591HCID 131732591, compound

Procedure

According to the Step 15-1 in the synthetic method for Example aa15, (2R)-2-acetyloxy-2-[(2R)-3-oxo-4-(2-oxo-1H-quinolin-7-yl)morpholin-2-yl]acetic acid (compound aa7-4) and 6-amino-3-(1,3-dioxoisoindol-2-yl)-1,2-benzisoxazole can be used to obtain [(1R)-2-[[3-(1,3-dioxoisoindol-2-yl)-1,2-benzisoxazol-6-yl]amino]-2-oxo-1-[(2R)-3-oxo-4-(2-oxo-1H-quinolin-7-yl)morpholin-2-yl]ethyl]acetate (compound ap2-1), then further treatment can be achieved according to the Step 15-2 to obtain the title compound ap2.

Sources & evidence

ORD record
ord-6947121feb7a4327990e51d0ed911450
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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