Sodium Carbonate → HCID 76717126, compound

Participants

Reaction Conditions

Reaction Steps

4-cyano-3-fluoroaniline (10 g, 0.073 mol) dissolved in EtOH (36 ml). Water (7.3 ml) was added followed by Na2CO3 (5.06 g, 0.65 eq) and the temperature of the mixture raised to 60° C. NH2OH.HCl (5.6 g, 1.1 eq) in water (7.3 ml) was added slowly, and the mixture heated at 60° C. overnight. The mixture was cooled to rt, the solid was collected by filtration, washed with, water (7 ml), EtOH (7 ml), ether (20 ml), and dried to give 7.5 g of M16-1.

Provenance & Evidence