m-Chloroperbenzoic acid → 8-Cyclopentyl-2-methanesulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one

Participants

Reaction Steps

A solution of 8-cyclopentyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine (10), (3.5 mmol) and MCPBA (5.25 mmol) in CH2Cl2 was stirred at room temperature for about 12 h. After completion of the reaction, the reaction mixture was washed with saturated NaHCO3. The organic layer was dried over Na2SO4, filtered away from the drying agent, and concentrated to give the desired product (11) which was used without further purification.

Provenance & Evidence