反应详情

3.05 g (13.5 mmol) 5-(trifluoromethyl)-1,3,4-thiadiazol-2-ylacetic acid ethyl ester [for preparation see DE 42 40 168-A1] are heated in 6.9 ml (40.5 mmol) dimethylformamide diethyl acetal overnight at 100° C. After cooling, the mixture is concentrated and the residue is purified by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient).

1. temperatureAfter cooling
2. concentrationthe mixture is concentrated
3. customthe residue is purified by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)