Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 876757Generated: October 30, 2026

HCID 136336834, compound → HCID 136336833, compound

https://huagongshe.com/reaction/876757

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 136336834HCID 136336834—
ReactantHCID 178418361HCID 178418361—
CatalystPalladiumHCID 23938—
ProductHCID 136336833HCID 13633683368%

Reaction Steps

5-Benzyloxy-6-[5-(4-fluoro-benzyl)-[1,3,4]oxadiazol-2-yl]-3-methyl-3H-pyrimidin-4-one oxime was hydrogenated at 1 atmosphere of hydrogen in the presence of equal weight of 10% Pd/C to give 68% yield of 6-[5-(4-fluoro-benzyl)-[1,3,4]oxadiazol-2-yl]-5-hydroxy-3-methyl-3H-pyrimidin-4-one oxime (COTI-HIV-1DOxime or, also referred to as COTI-HIV-1). Results are summarized below.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987272B2
Source datasetuspto-grants-2015_03
ORD IDord-bb3a593cd9cc4417872755f2c490f208
Source noteuspto-grants-2015_03