HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → thieno[3,2-b]pyridin-2-ylmethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Methyl thieno(3,2-b)pyridine-2-carboxylate | HCID 22047416 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | thieno[3,2-b]pyridin-2-ylmethanol | HCID 13220437 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a solution of methyl thieno[3,2-b]pyridine-2-carboxylate (C-3) (600 mg, 3.1 mmol) in 30 mL of anhydrous THF at 0° C. was added LiAlH4 (472 mg, 12.4 mmol) in anhydrous THF (25 mL) dropwise over 20 mins. The reaction mixture was stirred at 0° C. for 30 mins. MeOH was added and the resulting mixture was purified by chromatography to afford the title compound. MS (m/z): 166 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987269B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-2138c7819f3449468214c8c715a61627 |
| Source note | uspto-grants-2015_03 |