Thieno[2,3-b]pyridin-2-ylmethanol → Thieno[2,3-b]pyridin-2-ylmethanamine

HRID 876774Notes

Reaction equation

HRID 876774 reaction equation
[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[CH2:10]O.S1C2C(=[N:16]C=CC=2)C=C1CN>>[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[CH2:10][NH2:16]

Participants

3

Reactant 2

HCID 7162092Thieno[2,3-b]pyridin-2-ylmethanolHCID 67305714Thieno[3,2-b]pyridin-2-ylmethanamine

Product 1

HCID 67304785Thieno[2,3-b]pyridin-2-ylmethanamine

Procedure

Intermediate E was prepared from thieno[2,3-b]pyridine-2-ylmethanol (E-2) following similar procedures for synthesizing intermediate C from C-4, as described above. MS (m/z): 165 (M+1)+.

Sources & evidence

ORD record
ord-4c2299e36e2f4d7e80eb4cd330748d94
Source dataset
uspto-grants-2015_03
Patent number
US08987269B2

Reaction notes

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