Pyrazolo[1,5-a]pyriMidine-5-carbonitrile → Pyrazolo[1,5-a]pyrimidine-5-methanamine

HRID 876789Notes

Reaction equation

HRID 876789 reaction equation
[N:1]1[N:5]2[CH:6]=[CH:7][C:8]([C:10]#[N:11])=[N:9][C:4]2=[CH:3][CH:2]=1.S1C2=NC=CC=C2C(CN)=C1>>[N:1]1[N:5]2[CH:6]=[CH:7][C:8]([CH2:10][NH2:11])=[N:9][C:4]2=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 23156341Pyrazolo[1,5-a]pyriMidine-5-carbonitrileHCID 67305656HCID 67305656, compound

Product 1

HCID 67305688Pyrazolo[1,5-a]pyrimidine-5-methanamine

Procedure

Intermediate M was prepared from pyrazolo[1,5-a]pyrimidine-5-carbonitrile (M−1) following similar procedures for synthesizing intermediate J from J-4, as described above. MS (m/z): 149 (M+1)+.

Sources & evidence

ORD record
ord-cbbc6779e255437998c8fb9d672e3d26
Source dataset
uspto-grants-2015_03
Patent number
US08987269B2

Reaction notes

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