HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Quinoline-6-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-Quinolinecarboxylic acid | HCID 82571 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Quinoline-6-carbonyl chloride | HCID 12391963 | 99.8% |
Reaction Steps
To a mixture of quinoline-6-carboxylic acid (0-1) (2.0 g, 11.5 mmol) in CH2Cl2 (250 mL) was added 3 drops of DMF at 0° C., followed by oxalyl chloride (7.3 g, 57.5 mmol) dropwise. The resulting reaction was stirred at room temperature overnight, and then concentrated to afford the title compound (2.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987269B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-a32c4c7516d54483ba9baf7d0922695d |
| Source note | uspto-grants-2015_03 |