反应详情

To a solution of ethyl thiazolo[4,5-c]pyridine-2-carboxylate (R-3) (5 g, 24 mmol) in ethanol (100 mL) was added NaBH4 (0.9 g, 24 mmol) in portions at 0° C. The suspension was stirred at room temperature for 1 h, and then concentrated. The resulting residue was dissolved in EtOAc, washed with water. The organic layer was separated, dried over Na2SO4, concentrated in vacuo and purified by chromatography on silica gel to give the title compound. MS (m/z): 167 (M+1)+.

1. concentrationconcentrated
2. dissolutionThe resulting residue was dissolved in EtOAc
3. washwashed with water
4. customThe organic layer was separated
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo
7. custompurified by chromatography on silica gel