HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazolo[1,5-a]pyriMidine-5-carbonitrile → Pyrazolo[1,5-a]pyrimidine-5-methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazolo[1,5-a]pyriMidine-5-carbonitrile | HCID 23156341 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Pyrazolo[1,5-a]pyrimidine-5-methanamine | HCID 67305688 | 94% |
Reaction Steps
To a solution of pyrazolo[1,5-a]pyrimidine-5-carbonitrile (2-2) (620 mg, 4.31 mmol) in NH3 in MeOH (5 mL) was added Raney Ni (100 mg). The reaction mixture was stirred at room temperature for 3 h under H2. The mixture was filtered, and the filtrate was concentrated to afford the title compound (600 mg). MS (m/z): 149 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987269B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-9894752808144c3a9a1cd7a78ddd6107 |
| Source note | uspto-grants-2015_03 |