反应详情

2,6-Dichloropyridin-4-amine (3.0 g, 18 mmol) was carefully added to concentrated sulfuric acid (20 mL). The mixture was cooled in an ice bath, and fuming nitric acid (2.6 mL) was added dropwise via pipette. The mixture was warmed to room temperature and stirred for 1 h, then poured onto crushed ice, resulting in a white precipitate. The white precipitate was collected by filtration, washed with cold water, and dried to afford the title compound (3.7 g), which was used for next step without further purification.

1. temperatureThe mixture was cooled in an ice bath
2. additionpoured
3. customonto crushed ice
4. customresulting in a white precipitate
5. filtrationThe white precipitate was collected by filtration
6. washwashed with cold water
7. customdried