Hydrochloric Acid → HCID 56644349, compound

Participants

Reaction Steps

120 mg (0.2 mmol) (1-{4-[3-(4-Methanesulfonyl-phenyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutyl)-carbamic acid tert.-butyl ester, intermediate example Int-3-2, were stirred with 10 mL 4M hydrogen chloride in dioxane for 23 hours at room temperature. The solvent was evaporated and the residue was treated with saturated sodium bicarbonate solution (pH 9). After stirring for two hours 100 mL dichloromethane were added and stirring was continued for one hour. The organic phase was separated and the aqueous phase was extracted once more with dichloromethane (50 mL). The combined organic extracts were washed with water, brine, dried, filtrated and the solvent was evaporated. The crude product (97.8 mg) was purified by HPLC to yield 20.8 mg of the title compound.

Provenance & Evidence