Hydrazine hydrate (1:1) → 6-bromo-1H-indazol-3-amine

Participants

Reaction Conditions

Reaction Steps

The reaction mixture of 4-bromo-2-fluorobenzonitrile (10 g, 50 mmol), hydrazine hydrate (7.85 ml, 250 mmol) in n-butanol (60 mL) was heated at 130° C. for overnight. After cooling down to room temperature, the precipitated crystalline solid was filtered off and washed three times with ethyl acetate (15 mL each). The product was dried in vacuo (10.3 g).

Provenance & Evidence