P-Anisidine → HCID 178487932, compound

Participants

Reaction Conditions

Reaction Steps

A solution of trifluoro-3-oxa-butyrate (14.95 g, 81 mmol) and PPA (72 ml) was heated at 100° C. and then treated with p-anisidine (10 g, 81 mmol) portion wise. The reaction mixture was further heated to 150° C. and stirred for 2 h at 150° C. After cooling to RT, the reaction mixture was poured into a beaker containing ice water. After stirring for 20 min, the mixture was filtered, and the resulting solid was washed with water (˜3 L). The resulting pinkish-purple solid was dried under vacuum to provide 6-methoxy-2-(trifluoromethyl)quinolin -4-ol (11.58 g, 47.6 mmol, 58.6% yield), which was used without purification.

Provenance & Evidence