(6-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methoxy-phenyl)-amine → 6-(2-Aminopyrimidin-5-yl)-n-(3-methoxyphenyl)-1,3-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	(6-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methoxy-phenyl)-amine	HCID 58345945	—
Reactant	2-Amino-pyrimidine boronic acid pinacol ester	HCID 131732593	—
Product	6-(2-Aminopyrimidin-5-yl)-n-(3-methoxyphenyl)-1,3-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine	HCID 44181589	—

Reaction Steps

(6-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methoxy-phenyl)-amine was reacted with 2-amino-pyrimidine boronic acid pinacol ester using General Procedure A to give 118. NMR (CDCl3): 2.74 (3H, s), 3.90 (3H, s), 4.04 (3H, s), 5.28 (2H, br), 6.76 (1H, d), 6.99 (1H, br), 7.35 (1H, d), 7.34 (1H, t), 7.55 (1H, s), 9.38 (2H, s). MS: MH+ 363.22 (25%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08987280B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-3aad554a03314508b2c3b18df25f1e26
Source note	uspto-grants-2015_03