4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 44181708, compound

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Reaction Steps

6-Chloro-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 6 was reacted with pyridine-4-boronic acid pinacol ester using General Procedure A. Purification on silica yielded 123. NMR: (CDCl3): 3.89 (s, 3H, CH3), 4.14 (s, 3H, CH3), 6.89-6.92 (m, H, ArH), 7.16 (m, H, ArH), 7.25 (s, H, ArH), 7.41 (t, H, ArH, J=8.1 HZ), 7.49 (sbr, H, NH), 8.39 (dd, 2H, 2×ArH, J=1.5 Hz, 4.5 Hz), 8.80 (dd, 2H, 2×ArH, J=1.5 Hz, 4.5 Hz). MS: (ESI+) MH+=333.24

Provenance & Evidence