3-Pyridinylboronic acid → HCID 44181709, compound

Participants

Reaction Steps

6-Chloro-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 6, from Example 4, was reacted with pyridine-3-boronic acid using General Procedure A. Purification on silica yielded 124. NMR: (CDCl3): 3.88 (s, 3H, CH3), 4.13 (s, 3H, CH3), 6.88-6.90 (m, H, ArH), 7.16 (m, H, ArH), 7.30 (s, H, ArH), 7.38-7.46 (m, 2H, 2×ArH), 7.50 (sbr, H, NH), 8.72 (m, H, ArH), 8.79-8.82 (m, H, ArH) 9.76 (m, H, ArH). MS: (ESI+) MH+=333.24

Provenance & Evidence