5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-(4-(3-Methoxyphenoxy)-1-methyl-1h-pyrazolo[3,4-d]pyrimidin-6-yl)pyridin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine	HCID 2756555	—
Reactant	6-Chloro-4-(3-methoxy-phenoxy)-1-methyl-1h-pyrazolo[3,4-d]pyrimidine	HCID 58345959	—
Product	5-(4-(3-Methoxyphenoxy)-1-methyl-1h-pyrazolo[3,4-d]pyrimidin-6-yl)pyridin-2-amine	HCID 44181710	—

Reaction Steps

6-Chloro-4-(3-methoxy-phenoxy)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (80 mg) was coupled to 2-aminopyridine-5-boronic acid pinacol ester via General Procedure A. The product was purified by reverse phase HPLC to yield 47.3 mg of 125. MS (Q1) 349.2 (M)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08987280B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-4448b6d8d95d4673bf093407524ee417
Source note	uspto-grants-2015_03