(6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methanesulfonyl-benzyl)-amine → 6-(1h-Indazol-4-yl)-1-methyl-n-(3-(methylsulfonyl)benzyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Reaction Steps

(6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methanesulfonyl-benzyl)-amine was reacted with indazole boronic acid pinacol ester in General Procedure A. Purification on silica yielded 128. NMR (CDCl3) 3.03 (s, 3H, CH3), 4.20 (s, 3H, CH3), 5.13 (d, H, ArH, J=5.95 Hz), 5.84 (sbr, H, NH), 7.51-7.65 (m, 3H, 3×ArH), 7.79 (d, H, ArH, J=7.72 Hz), 7.91 (d, H, ArH, J=7.77 Hz), 7.93 (s, H, ArH), 8.09 (s, H, ArH), 8.39 (d, H, ArH, J=7.28 Hz), 9.04 (s, H, ArH), 10.13 (sbr, H, NH). MS: (ESI+) MH+=434.10

Provenance & Evidence