N-(6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N,N',N'-trimethyl-ethane-1,2-diamine → N1-(6-(1H-indazol-4-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N1,N2,N2-trimethylethane-1,2-diamine

Participants

Reaction Steps

N-(6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N,N′,N′-trimethyl-ethane-1,2-diamine was reacted with indazole boronic acid pinacol ester in General Procedure A. Purification on silica yielded 131. NMR: (CDCl3): 2.38 (s, 6H, 2×CH3), 2.73 (t, 2H, CH2, J=7.17 Hz), 3.54 (s, 311, CH3), 4.08 (m, 2H, CH2), 4.17 (s, 3H, CH3), 7.52 (t, H, ArH, J=7.77 Hz), 7.60 (d, H, ArH, J=8.27 Hz), 8.01 (s, H, ArH), 8.42 (d, H, ArH, J=7.23 Hz), 9.19 (s, H, ArH), 10.35 (sbr, H, NH). MS: (ESI+) MH+=351.18

Provenance & Evidence