(6-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methoxy-phenyl)-amine → 6-(1h-Indazol-4-yl)-n-(3-methoxyphenyl)-1,3-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	(6-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methoxy-phenyl)-amine	HCID 58345945	—
Reactant	HCID 178431105	HCID 178431105	—
Product	6-(1h-Indazol-4-yl)-n-(3-methoxyphenyl)-1,3-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine	HCID 44180267	—

Reaction Steps

(6-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methoxyphenyl)-amine was reacted with indazole boronic acid pinacol ester using General Procedure A to give 141. NMR (CDCl3): 2.78 (3H, s), 3.89 (3H, s), 4.14 (3H, s), 6.79 (1H, dd), 7.02 (1H, br. s), 7.25 (1H, m), 7.37 (1H, t), 7.54 (1H, t), 7.63-7.68 (2H, m), 8.45 (1H, d), 9.10 (1H, s), 10.11 (1H, br). MS: MH+ 386.20 (100%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08987280B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-69b0768e3f234283b82d77fe12705425
Source note	uspto-grants-2015_03