4,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidine → HCID 58345960, compound

HRID 876944Notes

Reaction equation

HRID 876944 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].Cl[C:12]1[N:17]=[C:16]([Cl:18])[N:15]=[C:14]2[N:19]([CH3:22])[N:20]=[CH:21][C:13]=12>>[Cl:18][C:16]1[N:15]=[C:14]2[N:19]([CH3:22])[N:20]=[CH:21][C:13]2=[C:12]([N:8]2[CH2:9][CH2:10][N:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:6][CH2:7]2)[N:17]=1

Participants

3

Reactant 2

HCID 2222474,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidineHCID 7091611-(Methylsulfonyl)piperazine

Product 1

HCID 58345960HCID 58345960, compound

Procedure

Reaction of 1-methanesulfonyl-piperazine with 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 5 by General Procedure B gave 6-chloro-4-(4-methanesulfonyl-piperazin-1-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine.

Sources & evidence

ORD record
ord-f8529e3babe04b848bc21b16d3147d1c
Source dataset
uspto-grants-2015_03
Patent number
US08987280B2

Reaction notes

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