4,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidine → HCID 58345939, compound

HRID 876946Notes

Reaction equation

HRID 876946 reaction equation
[NH:1]1[CH2:6][CH2:5][S:4](=[O:8])(=[O:7])[CH2:3][CH2:2]1.Cl[C:10]1[N:15]=[C:14]([Cl:16])[N:13]=[C:12]2[N:17]([CH3:20])[N:18]=[CH:19][C:11]=12>>[Cl:16][C:14]1[N:13]=[C:12]2[N:17]([CH3:20])[N:18]=[CH:19][C:11]2=[C:10]([N:1]2[CH2:6][CH2:5][S:4](=[O:8])(=[O:7])[CH2:3][CH2:2]2)[N:15]=1

Participants

3

Reactant 2

HCID 2222474,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidineHCID 6484228Thiomorpholine 1,1-dioxide

Product 1

HCID 58345939HCID 58345939, compound

Procedure

Reaction of thiomorpholine-1,1-dioxide with 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 5 by General Procedure B gave 6-chloro-4-(1,1-dioxo-thiomorpholin-4-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine.

Sources & evidence

ORD record
ord-bc9b958622ca485da91cfdbccec8544b
Source dataset
uspto-grants-2015_03
Patent number
US08987280B2

Reaction notes

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