2-(6-(Bromomethyl)pyridin-2-yl)propan-2-ol → 7-(5-methylfuran-2-yl)-3-(6-[1-hydroxy-1-methylethyl]pyrid-2-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

HRID 876959Notes

Reaction equation

HRID 876959 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[C:8]3[NH:16][N:15]=[N:14][C:9]=3[N:10]=[C:11]([NH2:13])[N:12]=2)=[CH:4][CH:3]=1.Br[CH2:18][C:19]1[N:24]=[C:23]([C:25]([OH:28])([CH3:27])[CH3:26])[CH:22]=[CH:21][CH:20]=1>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[C:8]3[N:16]=[N:15][N:14]([CH2:18][C:19]4[CH:20]=[CH:21][CH:22]=[C:23]([C:25]([OH:28])([CH3:26])[CH3:27])[N:24]=4)[C:9]=3[N:10]=[C:11]([NH2:13])[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 667183882-(6-(Bromomethyl)pyridin-2-yl)propan-2-olHCID 178423995HCID 178423995, compound

Product 1

HCID 445544847-(5-methylfuran-2-yl)-3-(6-[1-hydroxy-1-methylethyl]pyrid-2-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

Procedure

Prepared from 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine and 2-(6-bromomethylpyridine-2-yl)propan-2-ol by the alkylation method described in Example 36.

Sources & evidence

ORD record
ord-80666f1402104e2796660e92f4d2a26c
Source dataset
uspto-grants-2015_03
Patent number
US08987279B2

Reaction notes

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