(3-Methoxyphenyl)boronic acid → HCID 66718492, compound

HRID 876976Notes

Reaction equation

HRID 876976 reaction equation
Cl[C:2]1[C:3]2[NH:10][N:9]([NH2:11])[N:8]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([OH:22])([CH3:21])[CH3:20])[N:14]=3)[C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1>>[OH:22][C:19]([C:15]1[N:14]=[C:13]([CH2:12][N:8]2[C:4]3[N:5]=[CH:6][N:7]=[C:2]([C:29]4[CH:28]=[CH:27][CH:26]=[C:25]([O:24][CH3:23])[CH:30]=4)[C:3]=3[NH:10][N:9]2[NH2:11])[CH:18]=[CH:17][CH:16]=1)([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 86655321HCID 86655321, compound

Product 1

HCID 66718492HCID 66718492, compoundYield 37%

Procedure

Prepared as described in Example 20 from 7-chloro-3-(6-[1-hydroxy-1-methylethyl]pyridine-2-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-2-amine and 3-methoxyphenylboronic acid (0.08 g, 0.56 mmol) to give the title compound (68 mg, 37%) as a yellow solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-12d703b3150a438cbe9604063ad1f9b8
Source dataset
uspto-grants-2015_03
Patent number
US08987279B2

Reaction notes

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