Pyridine, 2-(bromomethyl)-6-[(difluoromethoxy)methyl]- → 3-(6-Difluoromethoxymethylpyridin-2-ylmethyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine

HRID 876987Notes

Reaction equation

HRID 876987 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[C:8]3[NH:16][N:15]=[N:14][C:9]=3[N:10]=[C:11]([NH2:13])[N:12]=2)=[CH:4][CH:3]=1.Br[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][O:26][CH:27]([F:29])[F:28])[N:20]=1>>[F:29][CH:27]([F:28])[O:26][CH2:25][C:21]1[N:20]=[C:19]([CH2:18][N:14]2[C:9]3[N:10]=[C:11]([NH2:13])[N:12]=[C:7]([C:5]4[O:6][C:2]([CH3:1])=[CH:3][CH:4]=4)[C:8]=3[N:16]=[N:15]2)[CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 66718386Pyridine, 2-(bromomethyl)-6-[(difluoromethoxy)methyl]-HCID 178423995HCID 178423995, compound

Product 1

HCID 667183543-(6-Difluoromethoxymethylpyridin-2-ylmethyl)-7-(5-methyl-2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine

Procedure

Prepared from 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamine and 2-bromomethyl-6-difluoromethoxymethylpyridine by the alkylation method described in Example 36.

Sources & evidence

ORD record
ord-a946816a0ca8480baba81b13468e8e96
Source dataset
uspto-grants-2015_03
Patent number
US08987279B2

Reaction notes

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