2-Bromo-3'-trifluoromethoxyacetophenone → HCID 178474419, compound

HRID 877024Notes

Reaction equation

HRID 877024 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]([F:15])([F:14])[F:13])[CH:6]=1)=O.[C:16]([NH:19][C:20]([NH2:22])=[NH:21])(=[O:18])[CH3:17]>C(#N)C>[F:13][C:12]([F:15])([F:14])[O:11][C:7]1[CH:6]=[C:5]([C:3]2[N:21]=[C:20]([NH:19][C:16](=[O:18])[CH3:17])[NH:22][CH:2]=2)[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 27786872-Bromo-3'-trifluoromethoxyacetophenoneHCID 178475102HCID 178475102, compound

Product 1

HCID 178474419HCID 178474419, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared according to described procedure using 2-bromo-1-[3-(trifluoromethoxy)phenyl]ethanone (1.7 g, 6.00 mmol) and acetyl guanidine (0.91 g, 9.01 mmol)) in acetonitrile (17 ml) to obtain 460 g of the product as a yellow solid; 1H NMR (300 MHz, CDCl3) δ 2.07 (s, 3H), 5.50 (s, 1H), 7.10-7.15 (m, 1H), 7.39 (t, J=7.8, 1H), 7.47-7.64 (m, 3H), 7.92 (s, 1H).

Sources & evidence

ORD record
ord-bae22cc242144aa399620efc6e37463a
Source dataset
uspto-grants-2015_03
Patent number
US08987278B2

Reaction notes

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