Water → HCID 86702525, compound

Participants

Reaction Steps

7 g (17.8 mmol) 8-Bromo-2,4-dichloro-3-phenylpyrimido[1,2-b]indazole were suspended in a mixture of 453 mL ethanol, 322 mL water and 173 mL tetrahydrofuran. After addition of 4.5 g (84.4 mmol) ammonium chloride and 7.5 g (114 mmol) zinc the mixture was stirred over night at room temperature. The mixture was filtered via a glass fibre filter, washed with THF and the organic solvents were removed. The residue was treated with a mixture of water and ethyl acetate and the organic phase was separated. The aqueous phase was extracted twice with ethyl acetate and the combined organic extracts were evaporated without prior drying because the product had already precipitated. 3.7 g (57.9%) of the title compound were isolated.

Provenance & Evidence