反应详情

温度

100 °C

To 620 mg (2.1 mmol) 2-Chloro-9-fluoro-3-phenylpyrimido[1,2-b]indazole (intermediate example Int-1-0) and 1.1 g (2.9 mmol) {1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl}carbamic acid tert-butyl ester in 7.2 mL 1,2 dimethoxyethane were added 3.8 mL aqueous sodium carbonate (10%) and 170 mg (0.2 mmol) 1,1 bis(diphenylphosphino)ferrocenedichloropalladium(II). The reaction mixture was stirred for 30′ in the microwave at 100° C. and subsequently evaporated to dryness. The residue (770 mg=72.7%) was used without further purification in the next step.

1. customsubsequently evaporated to dryness
2. customThe residue (770 mg=72.7%) was used without further purification in the next step