HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 877053Generated: October 30, 2026
Cyclopropylamine → (2-Chloro-9-fluoro-3-phenylpyrimido[1,2-b]indazol-4-yl)cyclopropylamine
https://huagongshe.com/reaction/877053
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 2,4-Dichloro-9-fluoro-3-phenylpyrimido[1,2-b]indazole | HCID 86702523 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (2-Chloro-9-fluoro-3-phenylpyrimido[1,2-b]indazol-4-yl)cyclopropylamine | HCID 86702530 | 52.7% |
Reaction Steps
1 g (7.5 mmol) 2,4-Dichloro-9-fluoro-3-phenylpyrimido[1,2-b]indazole (intermediate example Int-1-0, step 2) and 430 mg (8.4 mmol) cyclopropylamine were dissolved in 8.4 mL DMF and heated in the microwave for 20′ at 100° C. The solvent was evaporated and the residue was purified by chromatography on silicagel (eluents: dichloromethane/methanol) to yield 560 mg (52.7%) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987286B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-e0193c857f0b4dc69b3dd499d4e06351 |
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| Source note | uspto-grants-2015_03 |
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