Sodium Carbonate → HCID 86702534, compound

Participants

Reaction Steps

179 mg of the mixture described in step 1,3-(2-chloro-3-phenylpyrimido[1,2-b]indazol-8-yl)benzonitrile and the byproduct 3-[2-(3-cyanophenyl)-3-phenyl-pyrimido[1,2-b]indazol-8-yl]benzonitrile, 210.5 mg (0.56 mmol) {1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl}carbamic acid tert-butyl ester, 38.4 mg (0.047 mmol) bis(diphenylphosphino)ferrocenedichloropalladium(II) and 0.87 mL aqueous sodium carbonate solution (10%) in 1.6 mL dimethoxyethane were heated in the microwave oven for 60′ at 120° C. After the usual work up described in step 1, the mixture (239.4 mg) was used in the next step without further purification.

Provenance & Evidence