HCID 67973853, compound → HCID 57377871, compound

Participants

Reaction Steps

239.4 mg (1-{4-[8-(3-Cyanophenyl)-3-phenylpyrimido[1,2-b]indazol-2-yl]phenyl}-cyclobutyl)carbamic acid tert-butyl ester jointly with the byproduct 3-[2-(3-cyanophenyl)-3-phenylpyrimido[1,2-b]indazol-8-yl]benzonitrile were dissolved in 17 mL 4M hydrogen chloride in dioxane. After stirring over night at room temperature the solvent was evaporated to dryness and the residue was treated with saturated sodium bicarbonate solution. This aqueous solution was extracted three times with ethyl acetate. The combined organic extracts were worked up as already described. The residue was purified by column chromatography on silicagel (eluents: dichloromethane/methanol) and additional HPLC yielding 18.2 mg of the title compound.

Provenance & Evidence