反应详情

100 mg (0.18 mmol) {1-[4-(9-Bromo-3-phenylpyrimido[1,2-b]indazole-2-yl)phenyl]-cyclobutyl}carbamic acid tert-butyl ester (intermediate example Int-2-0), 51.6 mg (0.35 mmol) (3-cyanophenyl)boronic acid, 14.3 mg (0.02 mmol) bis(diphenylphosphino)ferrocenedichloropalladium(II) and 55 mg (0.53 mmol) sodium carbonate in 1.8 mL dioxane and 0.3 mL water were heated in a microwave vial which had been sealed with a microwave cap for 18 hours at 105° C. (heating block). After the usual work up, the crude mixture (131.2 mg) was used in the next step without further purification.

1. customhad been sealed with a microwave
2. customcap for 18 hours at 105° C.
3. temperature(heating block)
4. customAfter the usual work up, the crude mixture (131.2 mg) was used in the next step without further purification