HCID 86702539, compound → HCID 67991223, compound

Participants

Reaction Steps

235 mg (1-{4-[10-(4-Cyanophenyl)-3-phenylpyrimido[1,2-b]indazol-2-yl]phenyl}-cyclobutyl)carbamic acid tert-butyl ester in 15 mL 4M hydrogen chloride in dioxane were stirred over night at room temperature. The solvent was evaporated and the residue was treated with saturated sodium bicarbonate. After extraction with dichloromethane (trice) the combined organic phases were washed with brine and dried (sodium sulfate). The solvent was evaporated and the residue (189 mg) was purified by HPLC yielding 50 mg of the title compound.

Provenance & Evidence