HCID 86702544, compound → HCID 57378749, compound

Participants

Reaction Steps

275 mg of the crude (E)-3-{2-[4-(1-tert-Butoxycarbonylaminocyclobutyl)phenyl]-3-phenylpyrimido[1,2-b]indazol-7-yl}acrylic acid methyl ester were stirred in 15 mL 4M hydrogen chloride in dioxane for 18 hours at room temperature. The solvent was evaporated and the residue was stirred with saturated sodium bicarbonate for one hour at room temperature. After addition of dichloromethane stirring was continued for another hour. The organic phase was separated and the aqueous phase was extracted once more with dichloromethane. The combined organic extracts were washed with water and brine, dried and filtrated. The solvent was evaporated and the residue purified by HPLC 35.7 mg (15.7%) of the title compound.

Provenance & Evidence