Acrylamide → HCID 86702545, compound

Participants

Reaction Steps

200 mg (0.351 mmol) {1-[4-(7-Bromo-3-phenylpyrimido[1,2-b]indazol-2-yl)phenyl]-cyclobutyl}carbamic acid tert-butyl ester (intermediate example Int-2-1), 49.9 mg (0.7 mmol) acrylamide, 18.2 mg (0.06 mmol) tri-2-tolylphosphane and 7.9 mg (0.035 mmol) palladium(II) acetate were treated in 2.47 mL degassed acetonitrile as described in example 13 (step 1). After the work-up 281 mg (>100%) of the crude product were obtained and used in the next step without further purification.

Provenance & Evidence