HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl phosphite → HCID 86668475, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl phosphite | HCID 8472 | — |
| Reactant | 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- | HCID 11325 | — |
| Product | HCID 86668475 | HCID 86668475 | 61.2% |
Reaction Steps
A mixture of 2-(2-bromoethyl)isoindoline-1,3-dione (7.62 g, 30 mmol) and trimethyl phosphite (100 g) was refluxed under N2 atmosphere for 10 hours. Concentration and purification through column chromatography on silica gel (100% EtOAc) gave the desired product as a white solid (5.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987284B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-80a421339ce743de9d2ce0ce3740f0c9 |
| Source note | uspto-grants-2015_03 |