HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 877094Generated: October 25, 2026
Cesium carbonate → 2-Methyl-5-(2-methyl-4-nitrophenoxy)pyridine
https://huagongshe.com/reaction/877094
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Methyl-5-hydroxypyridine | HCID 14275 | — |
| Reactant | Benzene, 1-chloro-2-methyl-4-nitro- | HCID 83315 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Methyl-5-(2-methyl-4-nitrophenoxy)pyridine | HCID 17990102 | — |
Reaction Steps
The mixture of 1-chloro-2-methyl-4-nitrobenzene (17.2 g), 6-methylpyridin-3-ol (12 g) and Cs2CO3 (39 g) in DMF (150 mL) was heated at 110° C. for 4 h. The solid was filtered and water (100 mL) and EtOAc (200 mL) were added. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The obtained yellow solid was used for the next step directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08987284B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-33ca47bf8b6d4e3fa5d1d616b29da37c |
|---|
| Source note | uspto-grants-2015_03 |
|---|
