Benzyl 4-((dimethylphosphinoyl)methyl)piperazine-1-carboxylate → 1-[(Dimethylphosphoryl)methyl]piperazine

Participants

Reaction Steps

To a flask was charged with benzyl 4-((dimethylphosphinoyl)methyl)piperazine-1-carboxylate (200 mg) and 10% palladium on carbon in methanol (20 mL). The mixture was stirred at room temperature under H2 atmosphere. The mixture was filtered through Celite and all solvents were removed under reduced pressure to give a white crystalline solid, which was used without further purification. LCMS ESI(+) m/z: 177 (M+1).

Provenance & Evidence