2-Bromo-1-(3-fluorobenzyloxy)-4-nitrobenzene → 3-Bromo-4-[(3-fluorophenyl)methoxy]aniline

Participants

Reaction Steps

A solution of (1-((2-bromo-4-nitrophenoxy)methyl)-3-fluorobenzene (3.26 g) in methanol (50 mL) with palladium on carbon (10%, 300 mg) was hydrogenated on a Parr shaker for 24 hours at 60 psi. The mixture was filtered through Celite and all solvents were removed under reduced pressure to give a white crystalline solid, which was used without further purification. LCMS ESI(+) m/z: 297 (M+1).

Provenance & Evidence