反应详情

A suspension of compound 16.1 (2.71 g, 10 mmol) and palladium 10% on carbon (1.0 g, wet) in methanol (40 mL) was hydrogenated under a hydrogen balloon for 14 hours. The reaction mixture was then filtered through Celite (20 g), rinsed with dichloromethane/methanol (3/1), and concentrated to give the title compound as a white crystalline solid (2.40 g, 100%). The product is used without further purification. LCMS ESI(+) m/z: 242 (M+1).

1. customfor 14 hours
2. filtrationThe reaction mixture was then filtered through Celite (20 g)
3. washrinsed with dichloromethane/methanol (3/1)
4. concentrationconcentrated